The Computer Science Colloquium

Sjors Scheres
(National Center for Biotechnology in Madrid, Spain)

"Maximum Likelihood Classification of Conformational States of Macromolecules in 3D Electron Microscopy"

Although three-dimensional electron microscopy permits structural characterization of macromolecular assemblies in distinct functional states, the inability to classify projection data from structurally heterogeneous samples has severely limited its application. We present a maximum likelihood-based classification method that does not depend on prior knowledge about the structural variability in the sample, and demonstrate its effectiveness for several experimental datasets.

The Colloquium is supported by generous contributions from the Bloomberg, Information Builders, Inc., and Netlogic, Inc.